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Article

BIGwas: Single-command quality control and association testing for multi-cohort and biobank-scale GWAS/PheWAS data.

GigaScience - 29 Jun 2021

Kässens Jan Christian, Wienbrandt Lars, Ellinghaus David

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) and phenome-wide association studies (PheWAS) involving 1 million GWAS samples from dozens of population-based biobanks present a considerable computational challenge and are carried out by large scientific groups under great expenditure of time and personnel. Automating these processes requires highly efficient and scalable methods and software, but so far there...

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PMID: 34184051
DOI: 10.1093/gigascience/giab047
PMCID: PMC8239664

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