Article

Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy

2021-10-07

Abstract excerpt

<h4>Background</h4> Polypoidal choroidal vasculopathy (PCV), a subtype of age-related macular degeneration (AMD), is characterized by polyp-like dilatation of blood vessels and turbulent blood flow in the choroid of the eye. Gold standard anti-vascular endothelial growth factor (anti-VEGF) therapy often fails to regress polypoidal lesions in patients. Current animal models have also been hampered by their inabili...

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Literature Corpus work: f630d83f-32a0-5f7b-b63f-80fcb2c65395
DOI: 10.1101/2021.10.06.463357

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