Article

Pallidal deep brain stimulation alters cortico-striatal synaptic communication in dystonic hamsters

2020-10-25

Abstract excerpt

<h4>Background</h4> Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is considered to be the most relevant therapeutic option for patients with severe dystonias, which are thought to arise from a disturbance in striatal control of the GPi, possibly resulting in thalamic disinhibition. The mechanisms of GPi-DBS are far from understood. Hypotheses range from an overall silencing of target nuclei (...

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Literature Corpus work: a136bbec-dfce-58e7-b2fa-1e477e65a32a
DOI: 10.1101/2020.10.25.353847

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