Article

Presynaptic filopodia form kinapses and modulate membrane mechanics for synchronous neurotransmission and seizure generation

2024-10-07

Abstract excerpt

The structural stability of synapses directly contrasts with their functional plasticity. This conceptual dichotomy is explained by the assumption that all synaptic plasticity is generated via either electrical and/or biochemical signaling. Here, we challenge this dogma by revealing an activity-dependent presynaptic response that is physical in nature. We show that dynamic filopodia emerge during action potential...

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Literature Corpus work: f5f7a1e6-9839-5990-b686-35decd80d5dd
DOI: 10.1101/2024.10.07.616970

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