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Article

Association of two variants in SMAD7 with the risk of congenital heart disease in the Han Chinese population.

PloS one - 1 Jan 2013

Wang Erli, Jin Wenfei, Duan Wenyuan, Qiao Bin, Sun Shuna, Huang Guoying, Shi Kaihu, Jin Li, Wang Hongyan

Abstract excerpt

SMAD7 is a general antagonist of TGF-β signaling and has been found to be involved in cardiogenesis in mouse models, but its role in human congenital heart disease (CHD) has yet to be investigated. To examine if SMAD7 is associated with CHD, we conducted a case-control study in the Han Chinese population. Exon1 and exon4 of SMAD7, which encode the functional MH1 and MH2 domains, were directly sequenced in 1,201...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24039762
DOI: 10.1371/journal.pone.0072423
PMCID: PMC3764115

Genes

SMAD7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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