Article

AGO1 in neural progenitor cells orchestrates brain development and sociability via LIN28A-REELIN axis

2025-10-02

Abstract excerpt

AGO1, an essential RNA binding protein (RBP) in RNA interference, is associated with autism spectrum disorder (ASD). However, the precise functions of AGO1 in brain development and related disorders remain largely unexplored. Here, we report the critical roles of AGO1 in neural progenitor cells (NPCs) in promoting sociability and shaping the structure of the developing brain. Ago1 knockout (KO) in the mouse brain...

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Literature Corpus work: f5eecfb3-f144-5ef3-8f2c-75e6867f4702
DOI: 10.1101/2025.10.01.679670

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