Article

SMARCAL1 is a candidate therapeutic target for ALT-positive tumors

2026-02-16

Abstract excerpt

A significant subset of tumors, including over 50% of osteosarcomas—an aggressive bone malignancy affecting children, adolescents, and young adults—relies on alternative lengthening of telomeres (ALT), a telomerase-independent, DNA repair-based mechanism for telomere elongation. The overall 5-year survival rate for osteosarcoma patients is ∼65%, underlying the need to develop novel targeted therapies. Through the...

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Literature Corpus work: f5c2856a-c274-5be5-ac09-4fe6a378389a
DOI: 10.64898/2026.02.15.704070

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