Article

Lineage-specific CDK activity dynamics characterize early mammalian development

2024-06-14

Abstract excerpt

<h4>ABSTRACT</h4> Cyclin-dependent kinases (CDK) are key regulatory enzymes that regulate proliferation dynamics and cell fate in response to extracellular inputs. It remains largely unknown how CDK activity fluctuates and influences cell commitment in vivo during early mammalian development. Here, we generated a transgenic mouse model expressing a CDK kinase translocation reporter (KTR) that enabled quantificat...

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Literature Corpus work: f5969b40-e7b4-5af2-a9aa-49a978a2e823
DOI: 10.1101/2024.06.14.599098

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