Article

Investigating BPDE-induced embryonic toxicity employing hiPSC-based models

2024-12-20

Abstract excerpt

Benzo[a]pyrene diol epoxide (BPDE) is a metabolite of the environmental contaminant Benzo[a]pyrene- a byproduct of incomplete combustion of organic matter. BPDE reacts with DNA to form BPDE-DNA bulky adducts which if not removed can lead to mutations due to DNA base-pair substitutions. While the effects of BPDE on somatic cells are fairly well described, its effects on early human development are currently unknown...

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Literature Corpus work: f90737e7-a1ad-5ea4-a3ad-539e16456532
DOI: 10.1101/2024.12.16.628678

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