Article

S-nitrosoglutathione reductase deficiency causes aberrant placental S-nitrosylation and preeclampsia

2020-07-02

Abstract excerpt

<h4>ABSTRACT</h4> Preeclampsia (PE), a leading cause of maternal and fetal mortality and morbidity, is characterized by an increase in S-nitrosylated (SNO) proteins and reactive oxygen species (ROS), suggesting a pathophysiologic role for dysregulation in nitrosylation and nitrosative stress. Here we show that mice lacking S-nitrosoglutathione reductase ( GSNOR −/− ), a denitrosylase regulating protein S-nitros...

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Literature Corpus work: f58d1a84-3c41-53ab-8e28-5b87f6dfc00e
DOI: 10.1101/2020.07.01.183012

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