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Article

Nitroso-Redox Balance and Mitochondrial Homeostasis Are Regulated by <i>STOX1</i> , a Pre-Eclampsia-Associated Gene

16 Apr 2014

Abstract excerpt

AIMS: Storkhead box 1 (STOX1) is a winged-helix transcription factor that is implicated in the genetic forms of a high-prevalence human gestational disease, pre-eclampsia. STOX1 overexpression confers pre-eclampsia-like transcriptomic features to trophoblastic cell lines and pre-eclampsia symptoms to pregnant mice. The aim of this work was to evaluate the impact of STOX1 on free radical equilibrium and...

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Share to Maternal and fetal healthcare
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Identifiers

PMID: 24738702
DOI: 10.1089/ars.2013.5661

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Related research

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Research trail→

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Nitroso-Redox Balance and Mitochondrial Homeostasis Are Regulated by <i>STOX1</i> , a Pre-Eclampsia-Associated GenePMID 24738702Read ↗

Functional Evaluation of STOX1 (STORKHEAD-BOX PROTEIN 1) in Placentation, Preeclampsia, and Preterm Birth.Semantic proximity Read ↗

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The pre-eclampsia gene STOX1 controls a conserved pathway in placenta and brain upregulated in late-onset Alzheimer's disease.Semantic proximity Read ↗

STOX2 but not STOX1 is differentially expressed in decidua from pre-eclamptic women: data from the Second Nord-Trondelag Health Study.Semantic proximity Read ↗

Endothelial cell dysfunction and cardiac hypertrophy in the STOX1 model of preeclampsiaSemantic proximity Read ↗

STOX1 Overexpression in Choriocarcinoma Cells Mimics Transcriptional Alterations Observed in Preeclamptic PlacentasSemantic proximity Read ↗

STOX1: Key player in trophoblast dysfunction underlying early onset preeclampsia with growth retardation.Semantic proximity Read ↗

The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation.Semantic proximity Read ↗

Association of <em>STOX1</em> Maternal and Fetal Polymorphisms with Hypertensive Disorders of Pregnancy: Preliminary Evidence for a Parent-of-Origin Effect and Maternal-Fetal Genotypic InteractionSemantic proximity Read ↗

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