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Article

Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis

21 Sept 2021

Abstract excerpt

Control of mRNA stability and degradation is essential for appropriate gene expression, and its dysregulation causes various disorders, including cancer, neurodegenerative diseases, diabetes, and obesity. The 5′–3′ exoribonuclease XRN1 executes the last step of RNA decay, but its physiological impact is not well understood. To address this, forebrain-specific Xrn1 conditional knockout mice ( Xrn1 -cKO) were...

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PMID: 34646989
DOI: 10.1016/j.isci.2021.103151

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