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Transcriptomics of acute injured lungs reveals IGF1R action on DNA damage response, metabolic reprogramming, mitochondrial homeostasis and epigenetics

2024-10-14

Abstract excerpt

<title>Abstract</title> <p>Background. Acute lung injury (ALI), ARDS and COVID-19 usually involve a “cytokine storm”. Insulin-like growth factor receptor 1 (IGF1R) maintains lung homeostasis and is implicated in these pulmonary inflammatory diseases. In mice, widespread IGF1R deficiency was reported to counteract respiratory inflammation and alveolar damage after bleomycin (BLM)-induced ALI. Methods. To explore...

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Literature Corpus work: 3c3f7896-3070-561a-8779-4f79bf4770dd
DOI: 10.21203/rs.3.rs-5224854/v1

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