Article

LiverMap pipeline for 3D imaging of human liver reveals volumetric spatial dysregulation of cirrhotic vasculobiliary architecture

2024-09-19

Abstract excerpt

The liver contains an intricate microstructure that is critical for liver function. Architectural disruption of this spatial structure is pathologic. Unfortunately, 2D histopathology – the gold standard for pathological understanding of many liver diseases – can misrepresent or leave gaps in our understanding of complex 3D structural features. Here, we utilized immunostaining, tissue clearing, microscopy, and comp...

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Literature Corpus work: f568034f-c0f6-5a43-bac6-3edf057fec58
DOI: 10.1101/2024.09.14.613049

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