Article

Convergent suppression of nuclear-encoded mitochondrial fatty acid oxidation genes defines a pan-subtype signature in breast cancer: a multi-cohort transcriptomic study

2026-05-20

Abstract excerpt

<h4>Background</h4> Breast cancer exhibits extensive molecular heterogeneity across intrinsic subtypes, yet convergent metabolic reprogramming may represent an obligate feature of tumour initiation. We hypothesised that suppression of nuclear-encoded mitochondrial fatty acid oxidation (FAO) constitutes such a convergence point, defining a shared metabolic phenotype independent of subtype. <h4>Methods</h4> RNA-se...

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Literature Corpus work: f5667dec-f741-5e1d-b1c0-888a4ce9edb5
DOI: 10.64898/2026.05.17.725700

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