Back to search

Article

A lenvatinib-resistance-derived transcriptional program identifies metabolic identity remodeling associated with unfavorable survival in hepatocellular carcinoma

2026-08-24

Abstract excerpt

<h4>Background: </h4> Metabolic adaptation is a recognized feature of therapeutic resistance in hepatocellular carcinoma (HCC), but it is unclear whether transcriptional states exposed during acquired resistance are restricted to drug adaptation or reflect broader aggressive tumor biology. We tested whether metabolic programs derived from a lenvatinib-resistance model identify a clinically adverse transcriptional...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e74583e1-8261-503e-9473-e2834e8abb52
DOI
10.64898/2026.08.21.746217
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A lenvatinib-resistance-derived transcriptional program identifies metabolic identity remodeling associated with unfavorable survival in hepatocellular carcinomaDOI 10.64898/2026.08.21.746217
Multiomics identifies metabolic subtypes based on fatty acid degradation allocating personalized treatment in hepatocellular carcinomaSemantic proximity
Robust Metabolic Transcriptional Components in 34,494 Patient-Derived Samples and Cell LinesSemantic proximity
Single-cell transcriptome analysis reveals the metabolic changes and the prognostic value of malignant hepatocyte subpopulations and predict new therapeutic agents for hepatocellular carcinomaSemantic proximity
Robust metabolic transcriptional components in 34,494 patient-derived samples and cell linesSemantic proximity
Metabolism‐associated molecular classification of hepatocellular carcinomaSemantic proximity
Convergent suppression of nuclear-encoded mitochondrial fatty acid oxidation genes defines a pan-subtype signature in breast cancer: a multi-cohort transcriptomic studySemantic proximity
A conserved immunometabolic transcriptional programme defines MASLD progression and is maintained in hepatocellular carcinomaSemantic proximity
Patient-derived HCC cells recapitulating the transcriptomic landscape of primary HCV-related liver cancerSemantic proximity
Construction and Validation of a Metabolic Reprogramming Related Prognostic Model for Hepatocellular CarcinomaSemantic proximity
Construction and validation of novel lactate metabolism molecular subtypes in hepatocellular carcinoma based on multi-omics analysisSemantic proximity
A Pan-Cancer Atlas of Metabolic Regulatory Circuitries Integrating Multi-Omic, Immune, and Clinical DimensionsSemantic proximity
Application of graph models to the identification of transcriptomic oncometabolic pathways in human hepatocellular carcinomaSemantic proximity
Select a neighboring publication to make it the new centre.