Article

Prediction of BAP1 mutations in uveal melanoma patients from histology images using weakly supervised deep learning-based whole slide image analysis

2021-09-22

Abstract excerpt

While cases of uveal melanoma are relatively rare overall, it remains the most common intraocular cancer in adults and has a 10-year fatality rate of approximately 50% in metastatic patients with no effective treatment options. Mutations in BAP1, a tumor suppressor gene, have been previously found to be associated with the onset of metastasis in uveal melanoma patients. In this study, I utilize a weakly supervised...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f55eca9b-3e1b-57ce-a347-360a5bed4aa9
DOI: 10.1101/2021.09.16.21263694

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Prediction of BAP1 mutations in uveal melanoma patients from histology images using weakly supervised deep learning-based whole slide image analysisDOI 10.1101/2021.09.16.21263694Read

Clinical and genetic characteristics of BAP1-mutated non-uveal and uveal melanoma.Semantic proximity Read

Prediction of molecular subclasses of uveal melanoma by deep learning using routine haematoxylin-eosin-stained tissue slides.Semantic proximity Read

XpressO-Melanoma: An Explainable Deep Learning Model for the Prediction of BRAF V600 Mutation Status in Cutaneous MelanomasSemantic proximity Read

A Deep Learning Approach for Rapid Mutational Screening in MelanomaSemantic proximity Read

BAP1 methylation: a prognostic marker of uveal melanoma metastasisSemantic proximity Read

Machine learning-based integrative analysis of methylome and transcriptome identifies novel prognostic DNA methylation signature in uveal melanomaSemantic proximity Read

Clinical Characteristics of Uveal Melanoma in Patients With Germline BAP1 Mutations.Semantic proximity Read

Molecular profiling of primary uveal melanoma: results of a Polish cohort.Semantic proximity Read

Interpreting Deep Learning-Based Prediction of the BRAF V600E Mutation Using Diagnostic Whole Slide Images in Skin Cutaneous Melanoma.Semantic proximity Read

Clinical significance of immunohistochemistry for detection of BAP1 mutations in uveal melanoma.Semantic proximity Read

A multi-omics deep learning model for hypoxia phenotype to predict tumor aggressiveness and prognosis in uveal melanoma for rationalized hypoxia-targeted therapySemantic proximity Read

Frequent mutation of BAP1 in metastasizing uveal melanomas.Semantic proximity Read