Article
Prediction of molecular subclasses of uveal melanoma by deep learning using routine haematoxylin-eosin-stained tissue slides.
Histopathology - 1 Dec 2024
Akram Farhan, de Bruyn Daniël P, van den Bosch Quincy C C, Trandafir Teodora E, van den Bosch Thierry P P, Verdijk Rob M, de Klein Annelies, Kiliç Emine, Stubbs Andrew P, Brosens Erwin, von der Thüsen Jan H
Abstract excerpt
AIMS: Uveal melanoma has a high propensity to metastasize. Prognosis is associated with specific driver mutations and copy number variations, and these can only be obtained after genetic testing. In this study we evaluated the efficacy of patient outcome prediction using deep learning on haematoxylin and eosin (HE)-stained primary uveal melanoma slides in comparison to molecular testing. METHODS: In this...
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