Article
Frequent mutation of BAP1 in metastasizing uveal melanomas.
Science (New York, N.Y.) - 3 Dec 2010
Harbour J William, Onken Michael D, Roberson Elisha D O, Duan Shenghui, Cao Li, Worley Lori A, Council M Laurin, Matatall Katie A, Helms Cynthia, Bowcock Anne M
Abstract excerpt
Metastasis is a defining feature of malignant tumors and is the most common cause of cancer-related death, yet the genetics of metastasis are poorly understood. We used exome capture coupled with massively parallel sequencing to search for metastasis-related mutations in highly metastatic uveal melanomas of the eye. Inactivating somatic mutations were identified in the gene encoding BRCA1-associated protein 1...
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