Article
Clinical and genetic characteristics of BAP1-mutated non-uveal and uveal melanoma.
Frontiers in immunology - 1 Jan 2024
Matull Johanna, Placke Jan-Malte, Lodde Georg, Zaremba Anne, Utikal Jochen, Terheyden Patrick, Pföhler Claudia, Herbst Rudolf, Kreuter Alexander, Welzel Julia, Kretz Julia, Möller Inga, Sucker Antje, Paschen Annette, Livingstone Elisabeth, Zimmer Lisa, Hadaschik Eva, Ugurel Selma, Schadendorf Dirk, Thielmann Carl Maximilian, Griewank Klaus Georg
Abstract excerpt
Background: Screening for gene mutations has become routine clinical practice across numerous tumor entities, including melanoma. BAP1 gene mutations have been identified in various tumor types and acknowledged as a critical event in metastatic uveal melanoma, but their role in non-uveal melanoma remains inadequately characterized. Methods: A retrospective analysis of all melanomas sequenced in our department...
Topics
- Humans
- Ubiquitin Thiolesterase
- Melanoma
- Uveal Neoplasms
- Male
- Tumor Suppressor Proteins
- Female
- Mutation
- Middle Aged