Article
Clinical significance of immunohistochemistry for detection of BAP1 mutations in uveal melanoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2014
Koopmans Anna E, Verdijk Robert M, Brouwer Rutger W W, van den Bosch Thierry P P, van den Berg Mike M P, Vaarwater Jolanda, Kockx Christel E M, Paridaens Dion, Naus Nicole C, Nellist Mark, van IJcken Wilfred F J, Kiliç Emine, de Klein Annelies
Abstract excerpt
Uveal melanoma is a lethal cancer with a strong propensity to metastasize. Limited therapeutic options are available once the disease has disseminated. A strong predictor for metastasis is the loss of chromosome 3. Inactivating mutations in BAP1 encoding the BRCA1-associated protein 1 and located on chromosome 3p21.1, have been described in uveal melanoma and other types of cancer. In this study, we determined...
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