Interpreting Deep Learning-Based Prediction of the BRAF V600E Mutation Using Diagnostic Whole Slide Images in Skin Cutaneous Melanoma.

Abstract excerpt

Deep learning (DL) models have shown promise in predicting molecular alterations directly from hematoxylin and eosin-stained whole slide images in a variety of solid tumors, offering a rapid alternative to conventional molecular testing. However, these models often offer limited insight into their decision-making process, undermining transparency and eroding clinical trust. Interpreting model predictions is...

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