Article

Calmodulin binds to the N-terminal domain of the cardiac sodium channel Na <sub>v</sub> 1.5

2020-06-03

Abstract excerpt

<h4>ABSTRACT</h4> The cardiac voltage-gated sodium channel Na v 1.5 conducts the rapid inward sodium current crucial for cardiomyocyte excitability. Loss-of-function mutations in its gene SCN5A are linked to cardiac arrhythmias such as Brugada Syndrome (BrS). Several BrS-associated mutations in the Na v 1.5 N-terminal domain exert a dominant-negative effect (DNE) on wild-type channel function, for which mechan...

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Literature Corpus work: f5440195-d909-5751-bb1a-e78916e357aa
DOI: 10.1101/2020.06.02.129288

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