Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Calcium-dependent regulation of the voltage-gated sodium channel hH1: intrinsic and extrinsic sensors use a common molecular switch.

Proceedings of the National Academy of Sciences of the United States of America - 7 Mar 2006

Shah Vikas N, Wingo Tammy L, Weiss Kevin L, Williams Christina K, Balser Jeffrey R, Chazin Walter J

Abstract excerpt

The function of the human cardiac voltage-gated sodium channel Na(V)1.5 (hH1) is regulated in part by binding of calcium to an EF hand in the C-terminal cytoplasmic domain. hH1 is also regulated via an extrinsic calcium-sensing pathway mediated by calmodulin (CaM) via binding to an IQ motif immediately adjacent to the EF-hand domain. The intrinsic EF-hand domain is shown here to interact with the IQ motif, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Calcium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Vitro Techniques

Share to Muscle Proteins

Share to Myocardium

Share to NAV1.5 Voltage-Gated Sodium Channel

Share to Peptide Fragments

Share to Sodium Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 16505387
DOI: 10.1073/pnas.0507397103
PMCID: PMC1450128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Calcium-dependent regulation of the voltage-gated sodium channel hH1: intrinsic and extrinsic sensors use a common molecular switch.PMID 16505387Read ↗

An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability.Semantic proximity Read ↗

A calcium sensor in the sodium channel modulates cardiac excitability.Semantic proximity Read ↗

Calcium-mediated dual-mode regulation of cardiac sodium channel gating.Semantic proximity Read ↗

The Crossroad of Ion Channels and Calmodulin in DiseaseSemantic proximity Read ↗

Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif.Semantic proximity Read ↗

Calmodulin binds to the N-terminal domain of the cardiac sodium channel Na <sub>v</sub> 1.5Semantic proximity Read ↗

Elementary mechanisms of calmodulin regulation of NaV1.5 producing divergent arrhythmogenic phenotypes.Semantic proximity Read ↗

Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins.Semantic proximity Read ↗

A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel.Semantic proximity Read ↗

Structural basis of human Nav1.5 gating mechanismsSemantic proximity Read ↗

Ca2+/calmodulin-dependent protein kinase II-based regulation of voltage-gated Na+ channel in cardiac disease.Semantic proximity Read ↗

Regulation of the Voltage-Gated Cardiac Sodium Channel Nav1.5 by Interacting ProteinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.