Article

Genetic models of latent tuberculosis in mice reveal differential control by adaptive immunity

2021-02-08

Abstract excerpt

Studying latent Mycobacterium tuberculosis (Mtb) infection has been limited by the lack of a suitable mouse model. We discovered that transient depletion of protein biotin ligase (BPL) and thioredoxin reductase (TrxB2) results in latent infections during which Mtb cannot be detected but that relapse in a subset of mice. The immune requirements for Mtb control during latency, and the frequency of relapse, were str...

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Literature Corpus work: f54205a7-4a45-5015-bcfb-8598ebee5384
DOI: 10.1101/2021.02.08.430271

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