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Article

In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice.

Nature medicine - 1 Dec 2007

Gandotra Sheetal, Schnappinger Dirk, Monteleone Mercedes, Hillen Wolfgang, Ehrt Sabine

Abstract excerpt

The success of Mycobacterium tuberculosis (Mtb) as a human pathogen relies on its ability to resist eradication by the immune system. The identification of mechanisms that enable Mtb to persist is key for finding ways to limit latent tuberculosis, which affects one-third of the world's population...

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Identifiers

PMID: 18059281
DOI: 10.1038/nm1683
PMCID: PMC3174471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18059281-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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