Article
Latent tuberculosis: models, mechanisms, and novel prospects for eradication.
Seminars in pediatric infectious diseases - 1 Oct 2002
Riska Paul F, Carleton Stephen
Abstract excerpt
Latent tuberculosis (TB) infects one-third of the world. We present evidence for the existence of a latent state of TB in humans, cite new approaches to diagnosis and treatment, and identify several models that attempt to mimic the latent state. Persistent infection in mice and in vitro systems of microaerophilic and/or anaerobic growth and nutrient starvation have been the most productive models in yielding...
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