Article

The microcephaly protein WDR62 regulates cellular purine metabolism through the HSP70/HSP90 chaperone machinery

2024-07-03

Abstract excerpt

Inherited mutations in WD repeat-containing protein 62 (WDR62) are associated with microcephaly ( MCPH2 ). While WDR62 plays important roles in mitosis and centriole biogenesis, additional WDR62 functions may cause abnormal brain growth. Here, we reveal a novel WDR62 role in the molecular chaperone network regulating purine metabolism. In response to hyperosmotic stress, WDR62 redistributes to purinosomes—phase-s...

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Literature Corpus work: f53a4165-d4ef-5823-9655-cedc08425636
DOI: 10.1101/2024.07.01.601630

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