Article

A quantitative model of human neurodegenerative diseases involving protein aggregation

2019-02-08

Abstract excerpt

Human neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and Amyotrophic lateral sclerosis involve protein aggregation and share many other similarities. It is widely assumed that the protein aggregates exhibit a specific molecular mode of toxic action. This paper presents a simple mathematical model arguing that clinical cognitive status relates to the energy available after subtracting...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f52a7e82-efb8-573d-a362-0fb12013495d
DOI: 10.1101/541243

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A quantitative model of human neurodegenerative diseases involving protein aggregationDOI 10.1101/541243Read

A quantitative model of human neurodegenerative diseases involving protein aggregationSemantic proximity Read

Reduced Abundance and Subverted Functions of Proteins in Prion-Like Diseases: Gained Functions Fascinate but Lost Functions Affect AetiologySemantic proximity Read

Mathematical Modeling of Protein Misfolding Mechanisms in Neurological Diseases: A Historical OverviewSemantic proximity Read

Protein Misfolding in Prion and Prion-Like Diseases: Reconsidering a Required Role for Protein Loss-of-FunctionSemantic proximity Read

Dysregulation of the secretory pathway connects Alzheimer’s disease genetics to aggregate formationSemantic proximity Read

Inherited neurodegenerative diseases: the one-hit model of neurodegenerationSemantic proximity Read

A physics-based model explains the prion-like features of neurodegeneration in Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosisSemantic proximity Read

A Systems-Level Theoretical Framework for Prion Disease Resolution Through Coordinated Suppression, Clearance, Disaggregation, and Functional Protein ReplacementSemantic proximity Read

The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseasesSemantic proximity Read

The ubiquitin protein catabolic disorders.Semantic proximity Read

Protein damage, ageing and age-related diseasesSemantic proximity Read

Genotype-property patient-phenotype relations suggest that proteome exhaustion can cause amyotrophic lateral sclerosis.Semantic proximity Read