Article

Dysregulation of the secretory pathway connects Alzheimer’s disease genetics to aggregate formation

2020-08-10

Abstract excerpt

A hallmark of amyloid disorders, such as Alzheimer’s disease, is aggregation of secreted proteins. However, it is largely unclear how the hundreds of secretory pathway proteins contribute to amyloid formation. We developed a systems biology framework that integrates expression data with protein-protein interaction networks to successfully estimate a tissue’s fitness for producing specific secreted proteins. Using...

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Literature Corpus work: 9f32f1cc-5661-5ac3-a80b-c4059954231a
DOI: 10.1101/2020.08.10.243634

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