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A Systems-Level Theoretical Framework for Prion Disease Resolution Through Coordinated Suppression, Clearance, Disaggregation, and Functional Protein Replacement

2026-02-24

Abstract excerpt

Prion diseases are fatal neurodegenerative disorders characterized by the misfolding of prion proteins into self-propagating aggregates that drive rapid neuronal dysfunction and death. Despite advances in understanding prion biology, existing approaches largely target isolated aspects of disease progression—such as reducing prion protein expression or inhibiting aggregation—without addressing the full pathological...

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Literature Corpus work
35df97a7-e1e5-573b-bbb6-dfa16c7feb85
DOI
10.14293/pr2199.003030.v1
Open publication

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A Systems-Level Theoretical Framework for Prion Disease Resolution Through Coordinated Suppression, Clearance, Disaggregation, and Functional Protein ReplacementDOI 10.14293/pr2199.003030.v1
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