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Bumped kinase inhibitor BKI-1708 interferes in cytokinesis and drives baryzoite stage conversion in the cyst-forming apicomplexan parasites <i>Toxoplasma gondii, Neospora caninum</i> and <i>Besnoitia besnoiti</i>

2025-10-24

Abstract excerpt

<h4>ABSTRACT</h4> Bumped kinase inhibitors (BKIs) have demonstrated safety and promising efficacy against various apicomplexan pathogens both in vitro and in vivo . However, in the closely related cyst-forming coccidians T. gondii , Neospora caninum and Besnoitia besnoiti , in vitro treatments with a range of BKIs induced the conversion of intracellular tachyzoites into atypical multinucleated complexes (MN...

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Literature Corpus work
f51ad20f-733c-592b-8988-55c6abf6cbbb
DOI
10.1101/2025.10.22.684074
Open publication

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Bumped kinase inhibitor BKI-1708 interferes in cytokinesis and drives baryzoite stage conversion in the cyst-forming apicomplexan parasites <i>Toxoplasma gondii, Neospora caninum</i> and <i>Besnoitia besnoiti</i>DOI 10.1101/2025.10.22.684074
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