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NEK kinase TcRDK2 controls differentiation, host-cell infection, and remodeling of the translation initiation machinery in <i>Trypanosoma cruzi</i>

2026-06-09

Abstract excerpt

<h4>ABSTRACT</h4> Trypanosoma cruzi , the etiologic agent of Chagas disease, alternates between replicative epimastigotes and amastigotes and non-dividing, mammal-infective metacyclic and bloodstream trypomastigotes. Protein phosphorylation is a major regulatory mechanism in trypanosomatids, whose kinomes reveal an expanded family of NIMA-related kinases (NEKs). Here, we investigated the role of T. cruzi RDK2 (R...

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Literature Corpus work
34faf9ca-4868-5778-8b06-e910e842476f
DOI
10.64898/2026.06.07.730777
Open publication

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