Article

Fibroblast Iron Metabolic Reprogramming Links Chronic Inflammation to Extracellular Matrix Remodeling and Pathological Ossification

2026-04-14

Abstract excerpt

<title>Abstract</title> <p>Joints and their associated ligamentous structures constitute a dynamic interface for immune–stromal interactions, and chronic inflammatory joint diseases are marked by a paradoxical coexistence of persistent inflammation and progressive structural remodeling, including fibrosis and ectopic bone formation. Using radiographic axial spondyloarthritis (r-axSpA) as a disease model, we ident...

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Literature Corpus work: 045eb7bd-b323-5815-94d4-c6acc00ccee7
DOI: 10.21203/rs.3.rs-9232122/v1

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