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Oncogenic MAPK pathway activation disrupts Schwann cell fate commitment, inducing congenital and progressive neuropathy in mice

2024-04-25

Abstract excerpt

RASopathies, rare congenital syndromes affecting multiple organ systems, often include peripheral neuropathy of unknown origin. While RASopathy-associated gene variants are proto-oncogenic, the impact of timing and mosaicism on pathogenicity remains poorly understood. Here, we investigate the links between Braf, a key mitogen-activated protein kinase (MAPK) effector, and peripheral neuropathy. By targeting Braf p...

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Identifiers and source

Literature Corpus work
497333cc-5c9a-5aef-a141-468c23cef107
DOI
10.1101/2024.04.24.590951
Open publication

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Oncogenic MAPK pathway activation disrupts Schwann cell fate commitment, inducing congenital and progressive neuropathy in miceDOI 10.1101/2024.04.24.590951
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