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Article

RASopathies: unraveling mechanisms with animal models.

Disease models & mechanisms - 1 Aug 2015

Jindal Granton A, Goyal Yogesh, Burdine Rebecca D, Rauen Katherine A, Shvartsman Stanislav Y

Abstract excerpt

RASopathies are developmental disorders caused by germline mutations in the Ras-MAPK pathway, and are characterized by a broad spectrum of functional and morphological abnormalities. The high incidence of these disorders (∼1/1000 births) motivates the development of systematic approaches for their efficient diagnosis and potential treatment. Recent advances in genome sequencing have greatly facilitated the...

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Identifiers

PMID: 26203125
DOI: 10.1242/dmm.020339
PMCID: PMC4527292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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