Article

Mitochondrial antigen-specific CD8⁺ T cells drive dopamine neuron neurodegeneration

2024-02-28

Abstract excerpt

<h4>Summary</h4> The progressive degeneration of dopamine (DA) neurons drives motor symptoms in Parkinson’s disease (PD). Whether this neuronal degeneration is due to cell-autonomous dysfunctions in DA neurons or to death signals generated by other cell types is a key problem to address. Recent evidence suggests that loss of function of the protein PINK1, linked to early-onset forms of PD, enhances the presentati...

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Literature Corpus work: f4abdde7-7a22-5804-bbe0-ea2d55d5b68a
DOI: 10.1101/2024.02.26.582098

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