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Article

Multistability and predominant hybrid phenotypes in a four node mutually repressive network of Th1/Th2/Th17/Treg differentiation.

NPJ systems biology and applications - 24 Oct 2024

Duddu Atchuta Srinivas, Andreas Elizabeth, Bv Harshavardhan, Grover Kaushal, Singh Vivek Raj, Hari Kishore, Jhunjhunwala Siddharth, Cummins Breschine, Gedeon Tomas, Jolly Mohit Kumar

Abstract excerpt

Elucidating the emergent dynamics of cellular differentiation networks is crucial to understanding cell-fate decisions. Toggle switch - a network of mutually repressive lineage-specific transcription factors A and B - enables two phenotypes from a common progenitor: (high A, low B) and (low A, high B). However, the dynamics of networks enabling differentiation of more than two phenotypes from a progenitor cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39448615
DOI: 10.1038/s41540-024-00433-6
PMCID: PMC11502801

Genes

CD4

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