Article
Patient Mutation Directed shRNA Screen Uncovers Novel Bladder Tumor Growth Suppressors.
Molecular cancer research : MCR - 1 Sept 2015
Hensel Jonathan, Duex Jason E, Owens Charles, Dancik Garrett M, Edwards Michael G, Frierson Henry F, Theodorescu Dan
Abstract excerpt
UNLABELLED: Next-generation sequencing (NGS) of human bladder cancer has revealed many gene alterations compared with normal tissue, with most being predicted to be "loss of function." However, given the high number of alterations, evaluating the functional impact of each is impractical. Here, we develop and use a high-throughput, in vivo strategy to determine which alterations are loss of function in tumor...
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