Back to search

Article

Novel ploidy-control genes ORP3 and GJB3 link aneuploidy to tumor cell invasion through microtubule and actin dynamics

2025-04-14

Abstract excerpt

<title>Abstract</title> <p>Aneuploidy is a hallmark of most cancer types, and it is closely related to cancer cell migration and invasion. However, the mechanistic association between aneuploidy and invasive potential of cancer cells is poorly understood. Here, we report that GJB3 and ORP3, two ploidy-control proteins identified in a previous RNAi screen, are highly expressed in ureter and bladder epithelium whil...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5d9260f3-6a7c-5e0e-8db5-d1b5d6ade6e9
DOI
10.21203/rs.3.rs-2520973/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Novel ploidy-control genes ORP3 and GJB3 link aneuploidy to tumor cell invasion through microtubule and actin dynamicsDOI 10.21203/rs.3.rs-2520973/v1
Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamicsSemantic proximity
Loss of GRLF1 induces aneuploidy and enhances bladder cancer cell migration and invasion by modulating actin dynamicsSemantic proximity
The Role of TKS5 in Chromosome Stability and Bladder Cancer ProgressionSemantic proximity
Aneuploidy as a promoter and suppressor of malignant growth.Semantic proximity
Patterns of Aneuploidy and Signaling Consequences in CancerSemantic proximity
Losing balance: the origin and impact of aneuploidy in cancerSemantic proximity
Genomic and Functional Approaches to Understanding Cancer AneuploidySemantic proximity
Impact of somatic mutations and transcriptomic alterations on cancer aneuploidy.Semantic proximity
Cell-cycle Checkpoints and Aneuploidy on the Path to Cancer.Semantic proximity
Aneuploidy in human cancer: new tools and perspectivesSemantic proximity
Understanding How Genetic Mutations Collaborate with Genomic Instability in Cancer.Semantic proximity
PARP1 Suppression Drives ROS Resistance in Aneuploid Cancer CellsSemantic proximity
Select a neighboring publication to make it the new centre.