Article
Role of FGFR3 in bladder cancer: Treatment landscape and future challenges.
Cancer treatment reviews - 1 Apr 2023
Ascione Claudia Maria, Napolitano Fabiana, Esposito Daniela, Servetto Alberto, Belli Stefania, Santaniello Antonio, Scagliarini Sarah, Crocetto Felice, Bianco Roberto, Formisano Luigi
Abstract excerpt
Bladder cancer is a heterogeneous malignancy and is responsible for approximately 3.2% of new diagnoses of cancer per year (Sung et al., 2021). Fibroblast Growth Factor Receptors (FGFRs) have recently emerged as a novel therapeutic target in cancer. In particular, FGFR3 genomic alterations are potent oncogenic drivers in bladder cancer and represent predictive biomarkers of response to FGFR inhibitors. Indeed,...
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