Article
Increased genomic instability and reshaping of tissue microenvironment underlie oncogenic properties of Arid1a mutations.
Science advances - 15 Mar 2024
D'Ambrosio Alessandro, Bressan Davide, Ferracci Elisa, Carbone Francesco, Mulè Patrizia, Rossi Federico, Barbieri Caterina, Sorrenti Elisa, Fiaccadori Gaia, Detone Thomas, Vezzoli Elena, Bianchi Salvatore, Sartori Chiara, Corso Simona, Fukuda Akihisa, Bertalot Giovanni, Falqui Andrea, Barbareschi Mattia, Romanel Alessandro, Pasini Diego, Chiacchiera Fulvio
Abstract excerpt
Oncogenic mutations accumulating in many chromatin-associated proteins have been identified in different tumor types. With a mutation rate from 10 to 57%, ARID1A has been widely considered a tumor suppressor gene. However, whether this role is mainly due to its transcriptional-related activities or its ability to preserve genome integrity is still a matter of intense debate. Here, we show that ARID1A is largely...
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