Article
Two enzymes in one; two yeast peroxiredoxins display oxidative stress-dependent switching from a peroxidase to a molecular chaperone function.
Cell - 28 May 2004
Jang Ho Hee, Lee Kyun Oh, Chi Yong Hun, Jung Bae Gyo, Park Soo Kwon, Park Jin Ho, Lee Jung Ro, Lee Seung Sik, Moon Jeong Chan, Yun Jeong Won, Choi Yeon Ok, Kim Woe Yeon, Kang Ji Seoun, Cheong Gang-Won, Yun Dae-Jin, Rhee Sue Goo, Cho Moo Je, Lee Sang Yeol
Abstract excerpt
Although a great deal is known biochemically about peroxiredoxins (Prxs), little is known about their real physiological function. We show here that two cytosolic yeast Prxs, cPrxI and II, which display diversity in structure and apparent molecular weights (MW), can act alternatively as peroxidases and molecular chaperones. The peroxidase function predominates in the lower MW forms, whereas the chaperone function...
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