Article

The Cyclophilin Inhibitor Rencofilstat Decreases HCV-induced Hepatocellular Carcinoma Independently of Its Antiviral Activity

2023-08-20

Abstract excerpt

There is an urgent need for the identification of new drugs that inhibit HCV-induced hepatocellular carcinoma (HCC). Our work demonstrates that cyclophilin inhibitors (CypI) represent such new drugs. We demonstrated that the non-immunosuppressive cyclosporine A (CsA) analog (CsAa) rencofilstat possesses dual therapeutic activities for the treatment of HCV infection and HCV-induced HCC. Specifically, we showed that...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f47aed71-c368-5740-9bcb-c2e52bf3a08c
DOI: 10.1101/2023.08.19.553982

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Cyclophilin Inhibitor Rencofilstat Decreases HCV-induced Hepatocellular Carcinoma Independently of Its Antiviral ActivityDOI 10.1101/2023.08.19.553982Read

Evaluation of a cyclophilin inhibitor in hepatitis C virus-infected chimeric mice in vivo.Semantic proximity Read

The combination of the NS5A and cyclophilin inhibitors results in an additive anti-HCV inhibition in humanized mice without development of resistance.Semantic proximity Read

Cyclophilin inhibitors: a novel class of promising host-targeting anti-HCV agentsSemantic proximity Read

Identification of cellular and viral factors related to anti‐hepatitis C virus activity of cyclophilin inhibitorSemantic proximity Read

Cyclophilin Inhibitors: An Emerging Class of Therapeutics for the Treatment of Chronic Hepatitis C InfectionSemantic proximity Read

Cyclosporine inhibits a direct interaction between cyclophilins and hepatitis C NS5A.Semantic proximity Read

The Cyclophilin Inhibitor SCY-635 Disrupts Hepatitis C Virus NS5A-Cyclophilin A ComplexesSemantic proximity Read

Current implications of cyclophilins in human cancersSemantic proximity Read

Chemical genetics approach to hepatitis C virus replication: cyclophilin as a target for anti‐hepatitis C virus strategySemantic proximity Read

Sensitivity of hepatitis C virus to cyclosporine A depends on nonstructural proteins NS5A and NS5B.Semantic proximity Read

The cyclophilin inhibitor SCY-635 suppresses viral replication and induces endogenous interferons in patients with chronic HCV genotype 1 infection.Semantic proximity Read

In vitro infection of immortalized primary hepatocytes by HCV genotype 4a and inhibition of virus replication by cyclosporin.Semantic proximity Read