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Article

Targeting the gut-liver-immune axis to treat cirrhosis.

Gut - 1 May 2021

Tranah Thomas Henry, Edwards Lindsey A, Schnabl Bernd, Shawcross Debbie Lindsay

Abstract excerpt

Cirrhotic portal hypertension is characterised by development of the decompensating events of ascites, encephalopathy, portal hypertensive bleeding and hepatorenal syndrome, which arise in a setting of cirrhosis-associated immune dysfunction (CAID) and define morbidity and prognosis. CAID describes the dichotomous observations that systemic immune cells are primed and display an inflammatory phenotype, while...

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Identifiers

PMID: 33060124
DOI: 10.1136/gutjnl-2020-320786

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