Article
A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis.
BMC medicine - 7 Dec 2017
Yoo Seungyeul, Wang Wenhui, Wang Qin, Fiel M Isabel, Lee Eunjee, Hiotis Spiros P, Zhu Jun
Abstract excerpt
BACKGROUND: Chronic hepatitis B virus (HBV) infection leads to liver fibrosis, which is a major risk factor in hepatocellular carcinoma (HCC) and an independent risk factor of recurrence after HCC tumor resection. The HBV genome can be inserted into the human genome, and chronic inflammation may trigger somatic mutations. However, how HBV integration and other genomic changes contribute to the risk of tumor...
Topics
- Base Sequence
- Carcinoma, Hepatocellular
- Cohort Studies
- DNA, Viral
- Female
- Genome, Human
- Hepatitis B virus
- Hepatitis B, Chronic
- Humans
- Liver Cirrhosis
- Liver Neoplasms