Article

Targeting Astrocytic Connexin 43 Mitigates Glutamate-Driven Motor Neuron Stress in Late-Onset Spinal Muscular Atrophy

2025-11-04

Abstract excerpt

5q-associated spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder caused by mutations in the survival of motor neuron-1 (SMN1) gene, leading to progressive muscle weakness, atrophy, and respiratory failure. Although traditionally considered a motor neuron (MN)–specific disease, recent research highlights the in-volvement of astrocytes, particularly in regulating extracellular glutamate l...

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Literature Corpus work: f4705cfe-f4dd-594b-ad99-a6beab569ea7
DOI: 10.20944/preprints202511.0226.v1

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