Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gap junctions in inherited human disorders of the central nervous system.

Biochimica et biophysica acta - 1 Aug 2012

Abrams Charles K, Scherer Steven S

Abstract excerpt

CNS glia and neurons express connexins, the proteins that form gap junctions in vertebrates. We review the connexins expressed by oligodendrocytes and astrocytes, and discuss their proposed physiologic roles. Of the 21 members of the human connexin family, mutations in three are associated with significant central nervous system manifestations. For each, we review the phenotype and discuss possible mechanisms of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Central Nervous System Diseases
Share to Charcot-Marie-Tooth Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Connexins

Share to Gap Junction beta-1 Protein

Share to Gap Junctions

Share to Genes, Recessive

Share to Neuroglia

Source

Open in PubMed Open full text

Identifiers

PMID: 21871435
DOI: 10.1016/j.bbamem.2011.08.015
PMCID: PMC3771870

Genes

GJA1
GJC2
GJB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gap junctions in inherited human disorders of the central nervous system.PMID 21871435Read ↗

Gap junction disorders of myelinating cells.Semantic proximity Read ↗

Diseases of connexins expressed in myelinating glia.Semantic proximity Read ↗

Molecular mechanisms of gap junction mutations in myelinating cells.Semantic proximity Read ↗

Mechanisms of Diseases Associated with Mutation in GJC2/Connexin 47.Semantic proximity Read ↗

Hereditary spastic paraplegia is a novel phenotype for GJA12/GJC2 mutations.Semantic proximity Read ↗

Connexins, gap junctions and peripheral neuropathy.Semantic proximity Read ↗

Gap junction communication in myelinating glia.Semantic proximity Read ↗

The role of connexins in human disease.Semantic proximity Read ↗

SnapShot: Connexins and Disease.Semantic proximity Read ↗

Human oligodendrocytes express Cx31.3: function and interactions with Cx32 mutants.Semantic proximity Read ↗

Pathologic and Phenotypic Alterations in a Mouse Expressing a Connexin47 Missense Mutation That Causes Pelizaeus-Merzbacher–Like Disease in HumansSemantic proximity Read ↗

How do mutations in GJB1 cause X-linked Charcot-Marie-Tooth disease?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.