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Article

Accelerated hippocampal spreading depression and enhanced locomotory activity in mice with astrocyte-directed inactivation of connexin43.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Feb 2003

Theis Martin, Jauch Regina, Zhuo Lang, Speidel Dina, Wallraff Anke, Döring Britta, Frisch Christian, Söhl Goran, Teubner Barbara, Euwens Carsten, Huston Joseph, Steinhäuser Christian, Messing Albee, Heinemann Uwe, Willecke Klaus

Abstract excerpt

Using a human glial fibrillary acidic protein (hGFAP) promoter-driven cre transgene, we have achieved efficient inactivation of a floxed connexin43 (Cx43) gene in astrocytes of adult mice. The loss of Cx43 expression was monitored in a cell-autonomous manner via conditional replacement of the Cx43-coding region by a lacZ reporter gene. In this way, we bypassed the early postnatal lethality previously reported for...

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PMID: 12574405
PMCID: PMC6741919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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