Article
Gap junction disorders of myelinating cells.
Reviews in the neurosciences - 1 Jan 2010
Kleopa Kleopas A, Orthmann-Murphy Jennifer, Sargiannidou Irene
Abstract excerpt
Gap junctions (GJs) are channels that allow the diffusion of ions and small molecules across apposed cell membranes. In peripheral nerves, Schwann cells express the GJ proteins connexin32 (Cx32) and Cx29, which have distinct localizations. Cx32 forms GJs through non-compact myelin areas, whereas Cx29 forms hemichannels in the innermost layers of myelin apposing axonal Shaker-type K+ channels. In the CNS, rodent...
Topics
- Animals
- Connexins
- Gap Junctions
- Humans
- Models, Biological
- Models, Molecular
- Mutation
- Myelin Sheath
- Nervous System Diseases
- Schwann Cells